Septelia Inawati Wanandi

Septelia Inawati Wanandi

Prof. Dr. rer. physiol. dr. Septelia Inawati Wanandi

Biokimia & Biologi Molekuler
Kepakaran :

Alamat :
Departemen Biokimia & Biologi Molekuler
Fakultas Kedokteran Universitas Indonesia
Jl. Salemba Raya No. 6, Jakarta Pusat 10430, INDONESIA

Email

Nomor Kontak

Index Scopus: https://www.scopus.com/authid/detail.uri?authorId=36099320700


FOKUS RISET

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RISET SEDANG BERJALAN

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PUBLIKASI

Sebagai Penulis Utama:

  1. Wanandi SI, Waldschmidt R, Seifart KH. Mammalian transcription factor PBP: Characterization of its binding properties to the proximal sequence element of U6 genes. Journal of Biological Chemistry. 1993;268(9):6629-6640.
  2. Wanandi SI. Distribution of genetic polymorphism of aldehyde dehydrogenase-2 (ALDH2) in Indonesian subjects. Medical Journal of Indonesia. 2002;11(3):135-143.
  3. Wanandi SI, Dewi S, Juswan SWA, Sadikin M. Expression of manganese superoxide dismutase in rat blood, heart and brain during induced systemic hypoxia. Medical Journal of Indonesia. 2011;20(1):27-33.
  4. Wanandi SI, Dewi S, Pramana S, Karsono R. The alteration of p53-pathway gene expression in advanced breast cancer after neoadjuvant chemo- and hormone therapy. Annals of Oncology. 2016; 27
  5. Wanandi SI, Yustisia I, Neolaka GMG, Jusman SWA. Impact of extracellular alkalinisation on the survival of human CD24/CD44+ breast cancer stem cells associated with cellular metabolic shifts. Brazillian Journal of Medical and Biological Research. 2017;50(8):e6538.
  6. Wanandi SI, Syahrani RA, Jusman SWA. The impact of rotenone-modulated oxidative stress on the survival of human breast cancer stem cells (CD24-/CD44+). Annals of Oncology. 2017;28.
  7. Wanandi SI, Purnamawati, Tamar A, Putri KT, Simadibrata DM. Analysis of ALDH1A1 and ALDH1A3 gene mRNA expressions in adipose-derived stem cells (ASCs) and umbilical cord stem cells (UCSCs). Indonesian Biomedical Journal. 2018;10(3):290-296.
  8. Wanandi SI, Hardiany NS, Siregar NC, Sadikin M. Suppression of manganese superoxide dismutase activity in rotenone-treated human glioblastoma T98G cells reduces cell viability. Asian Journal of Pharmaceutical and Clinical Research. 2018;11(1):48-54.
  9. Wanandi SI, Ningsih SS, AsikinH, Hosea R, Neolaka GMG. Metabolic interplay between tumour cells and cancer-associated fibroblasts (CAFs) under hypoxia versus normoxia. Malaysian Journal of Medical Sciences. 2018; 25(3):7-16.
  10. Wanandi SI, Wideani S, Zainuri M, Putri RR, Bachtiar EW, Jusman SWA. Evaluation of stemness and proliferation of huma breast cancer stem cells (ALDH+) supplemented with heat-activated TGF-β1 in the secretomes of stem cell from human exfoliated deciduous teeth (SHED). Annals of Oncology. 2018;29(13):13.
  11. Wanandi SI, Candra C, Dewi S, Karsono R. Expression of hypoxia-inducible factor-1 alpha and 2 alpha in advanced breast cancer after neoadjuvant therapy. Journal of International Dental and Medical Research. 2019;12(1):247-253.

Sebagai Penulis Pembantu:

  1. Waldschmidt R, Wanandi SI, Seifart KH. Identification of transcription factor required for the expression of mammalian U6 genes in vitro. Embo Journal. 1991;10(9):2595-2603.
  2. Meibner W, Wanandi SI, Carbon P, Krol A, Seifart KH. Transcription factors required for the expression of Xenopus laevis selenocysteine tRNA in vitro. Nucleis Acids Research. 1994;22(4):553-559.
  3. Kurniati V, Wanandi SI. Prion: The infectious protein in neurodegenerative diseases. Medical Journal of Indonesia. 1999;8(3):149-159.
  4. Gunawan I, Sudardjat SS, Wanandi SI. Effects of tomato juices (Lycopersium esculentum Mill) comsumption on plasma lycopene levels of male light smokers. Medical Journal of Indonesia. 2004;13(3):146-150.
  5. Ahda Y, Gromoll J, Soeharso P, Wanandi SI, Moeloek N. Single nucleotide polymorphisms of follicle-stimulating hormone receptor promoter and their impacts to the promoter activities. Medical Journal of Indonesia. 2004;13(4):205-214.
  6. Sosrosumihardjo R, Firmansyah A, Rasad A, Wanandi SI, Retno D. Effects of realimentation on small intestinal morphology and disaccharidase activity in malnutrition Sprague-Dawley rats. Medical Journal of Indonesia. 2006;15(4):208-216.
  7. Sorontou Y, Asih PBS, Wanandi SI, Ramelan W, Syarifuddin D. Malaria in Jayapura District, Papua Provincr, Indonesia and resistance to sulfadoxine-pyrimethamine. Medical Jornal of Indonesia. 2007;16(1):32-38.
  8. Ferdinal F, Suyatna FD, Wanandi SI, Sadikin M. Expression of B-type natriuretic peptide-45 (BNP-45) gene in the venticrular myocardial induced by systemic chronic hypoxia. Acta medica Indonesiana. 2009;41(3):136-143.
  9. Syam AF, Sadikin M, Wanandi SI, Rani AA. Molecular mechanism on healing process of peptic ulcer. Acta medica Indonesiana. 2009;41(2):95-98.
  10. Hendrawan S, Jusman SWA, Ferdinal F, Wanandi SI, Sadikin M. Expression of hypoxia inducible factor 1α (HIF-1α) gene and apoptosis in the heart induced by systemic hypoxia. Medical Journal of Indonesia. 2009;18(2):97-101.
  11. Kurniawan A, Dwintasari SW, Soetomenggolo HA, Wanandi SI. Detection of Cryptosporidium sp infection by PCR and modified acid fast staining from potassium dichromate preserved stool. Medical Journal of Indonesia. 2009;18(3):149-154.
  12. Jusman SWA, Halim A, Wanandi SI, Sadikin M. Expression of hypoxia-inducible factor-1alpha (HIF-1alpha) related to oxidative stress in liver of rat-induced by systemic chronic normobaric hypoxia. Acta medica Indonesiana. 2010;42(1):17-23.
  13. Ferdinal F, Suyatna DF, Wanandi SI, Sadikin M. Structural and morphological changes in rat ventricular myocardium induced by chronic systemic hypoxi. Acta medica Indonesiana. 2010;42(3):135-141.
  14. Muliaty D, Yusuf I, Setiabudy R, Wanandi SI. CYP2A6 gene polymorphisms impact to nicotine metabolism. Medical Journal of Indonesia. 2010;19(1):46-51.
  15. Hardiany NS, Sadikin M, Wanandi SI. Gene expression of manganese superoxide dismutase in human glioma cells. Medical Journal of Indonesia. 2010;19(1):21-25.
  16. Puspitaningrum R, Wanandi SI, Soegianto RR, Williams DR, Cossins AR. Myoglobin Expression in Chelonia mydas Brain, Heart and Liver Tissues. Hayati Journal of Biosciences. 2010;17(3):110-114.
  17. Syam AF, Simadibrata M, Wanandi SI, Sadikin M, Rani A. Gastric ulcers induced by systemic hypoxia. Acta medica Indonesiana. 2011;43(4):243-248.
  18. Margaret AL, Syaruddin E, Wanandi SI. Low activity of manganese superoxide dismutase (MnSOD) in blood of lung cancer patients with smoking history: Relationship to oxidative stress. Asian Pacific Journal of Cancer Prevention. 2011;12(11):3049-3053.
  19. Asmarinah, Saleh MI, Wanandi SI, Freisleben HJ, Hinsch E. Polyclonal VDAC3 antibody decreases human sperm motility: A novel approach to male contraception. Medical Journal of Indonesia. 2011;20(1):5-10.
  20. Puspitaningrum R, Wanandi SI, Soegianto RR, Sadikin M. Blood Gasses Contents of Green Turtle (Chelonia mydas) Hatch Treated by Different Temperatures. Hayati Journal of Biosciences. 2011;18(3):147-150.
  21. Sadikin M, Puspitaningrum R, Wanandi SI, Soegianto RR. Isolation and Characterization of Chelonia mydas Myoglobin. Hayati Journal of Biosciences. 2012;19(2):60-64.
  22. Flora R, Freisleben HK, Ferdinal F, Wanandi SI, Sadikin M. Correlation of hypoxia inducible factor-1α and vascular endothelium growth factor in rat myocardium during aerobic and anaerobic exercise. Medical Journal of Indonesia. 2012;21(3):133-140.
  23. Prijanti AR, Ranasasmita R, Sandara Y, Wanandi SI. Correlation between hypoxia inducible factor-1α and renin expression in rats kidney induced by cobalt chloride. Medical Journal of Indonesia. 2012;21(3):128-132.
  24. Hardiany NS, Mulyawan W, Wanandi SI. Correlation between oxidative stress and tumor grade in glioma cells from patients in Jakarta. Medical Journal of Indonesia. 2012;21(3):122-127.
  25. Handayani S, Santoso I, Freisleben HJ, Wanandi SI, Thomm M. Archaeal Life on Tangkuban Perahu-Sampling and Culture Growth in Indonesian Laboratories. Hayari Journal Biosciences. 2012;19(3):150-154.
  26. Rachmat FD, Rachmat J, Sastroasmoro S, Wanandi SI. Effect of allopurinol on oxidative stress and hypoxic adaptation response during surgical correction of tetralogy of fallot. Acta medica Indonesiana. 2013;45(2):94-100.
  27. Flora R, Ferdinal F, Hernowo BS, Wanandi SI, Sadikin M, Freisleben HJ. Myocardial damage after continuous aerobic and anaerobic exercise in rats. Medical Journal of Indonesiana. 2013;22(4):209-214.
  28. Dewajanthi AM, Lubis VK, Wanandi SI, Wahidiyat I, Freisleben HJ. A 65 BP deletion in band 3 gene of β-thalassemia patients in Indonesia. Southeast Asian Journal of Tropical Medicine and Public Health. 2014;45(1):183-186.
  29. Victor AA, Gondhowiardjo TD, Waspadji S, Wanandi SI, Suyatna FD, Muhiddin H. Effect of laser photocoagulation and bevacizumab intravitreal in proliferative diabetic retinopathy: Review on biomarkers of oxidative stress. Medical Journal of Indonesia. 2014;23(2):79-86.
  30. Wimardhani YS, Suniarti DF, Freisleben HJ, Wanandi SI, Siregar NC, Ikeda MA. Chitsosan exerts anticancer activity through induction of apoptosis and cell cycle arrest in oral cancer cells. Journal of Oral Science. 2014;56(2):119-126.
  31. Jusman SWA, Iswanti FC, Suyatna FD, Wanandi SI, Sadikin M. Cytoglobin expression in oxidative stressed liver during systemic chronic normobaric hypoxia and relation with HIF-1α. Medical Journal of Indonesia. 2014;23(3):133-138.
  32. Paramita R, Sadikin M, Sutandyo N, Wanandi SI. Effect of hypoxia-inducible factor-1α induction by CoCL2 on breasr cancer cell survival: Influence of cytochrome-c and surviving. Medical Journal of Indonesia. 2014;23(3):139-146.
  33. Krisnamurti DGB, Louisa M, Anggraeni E, Wanandi SI. Drug Efflux Transporters Are Overexpressed in Short-Term Tamoxifen-Induced MCF7 Breast Cancer Cells. Advanced in Pharmacological Sciences. 2016; 6702424.
  34. Hardiany NS, Sadikin M, Siregar N, Wanandi SI. The suppression of manganese superoxide dismutase decreased the survival of human glioblastoma multiforme T98G cells. Medical Journal of Indonesia. 2017;26(1):19-25.
  35. Winarto H, Tan MI, Sadikin M, Wanandi SI. ARIDIA expression is down-regulated by oxidative stress in endometriosis and endometriosis-associated ovarian cancer. Translational Oncogenomics. 2017; 9.
  36. Purnamawati, Pawitan JA, Rachman A, Lien IK, Wanandi SI. Secretomes of adipose and umbilical cord-derived stem cells affect ALDH1A1 expression in breast cancer stem cells. Advanced Science Letters. 2017;23(7):6701-6704.
  37. Hardiany NS, Mulyawan W, Siregar NC, Wanandi SI. Analysis of apoptosis and cell proliferation in glioma related to the tumor grade. Advanced Science Letters. 2017;23(7):6771-6773.
  38. Louisa M, Sugiarti L, Kurniawan SV, Wanandi SI. Curcumin increase anti-cancer activity of tamoxifen in MCF-7 breast cancer cells through the suppression of MDR1 mRNA expression. Advanced Science Letters. 2017;23(7):6838-6840.
  39. Yustisia I, Jusman SWA, Wanandi SI. Extracelullar 02 level and pH modulation affected the human breast cancer stem cells’ survival and steamness. Advanced Science Letters. 2017;23(7):6685-6689.
  40. Neolaka GMG, Yustisia, Sadikin M, Wanandi SI. The effect of extracellular alkalinisation on lactate metabolism of breast cancer stem cells: Overview of LDH-A, LDH-B, MCT1 and MCT4 gene expression. Journal of Physics: Conference Series. 2017;884(1):012033.
  41. Yustisia I, Jusman SWA, Wanandi SI. Effects of extracellular modulation through hypoxia on the glucose metabolism of human breast cancer stem cells. Journal of Physics: Conference Series. 2017; 884(1):012026.
  42. Kartolo WA, Pawitan JA, Harahap AR, Wanandi SI. PDGF-AB rich-trombocyte lysate supplementation from breast cancer patients increased the proliferation of breast cancer stem cells. Medical Journal of Indonesia. 2018;27(1):19-25.
  43. Paramita P, Wardhani BWK, Wanandi SI, Louisa M. Curcumin for the prevention of epithelial-mesenchymal transition in endoxifen-treated MCF-7 breast cancer cells. Asian Pacific Journal of Cancer Prevention. 2018;19(5):1243-1249.
  44. Dewi S, Syahrani RA, Sadikin M, Wanandi SI. The sensitivity of human breast cancer stem cells (ALDH+) against doxorubicin treatment is associated with PCNA and BIRC5 Gene Expressions. Hiroshima Journal of Medical Sciences. 2018;67:84-90.
  45. Siburian MD, Suriapranata IM, Wanandi SI. Pre-S2 Start Codon Mutation of Hepatitis B Virus Subgenotype B3 Effects on NF-ƘB Expression and Activation Huh7 Cell Lines. Viral Immunology. 2018;31(5):362-370.
  46. Ningsih SS, Sari DH, Antarianto RD, Wanandi SI, Jusman SWA. Expression ifof stemness markers in keloid tissue. Medical Journal of Indonesia. 2018;27(3):145-149.
  47. Tedjasukmana R, Purba JS, Wanandi SI, Suyatna FD. Neuroglobin correlates with cryptochrome-1 in obstructive sleep apnea with primary aldosteronism. PLosS ONE. 2018;13(9):e0204390.
  48. Sen LT, Septyani J, Halim J, Syahrani RA, Wanandi SI. The association of HIF-2α expression with stemness and survival genes in huma breast cancer stem cells (CD24-/CD44+) exposed to hypoxia. 2018;1073(3):032066.
  49. Handoko H, Ichwan S, Wanandi SI, Hardiany NS. mRNA expression of tumor growth factor-βeta1 in human glioma. Journal of Physics: Conference Series. 2018;1073(3):032058.
  50. Tango T, Ichwan S, Wanandi SI, Hardiany NS. Relative expression of aldehyde dehydrogenase 1 family member A1 in different malignancies of human glioma cells. Journal of Physics: Conference Series. 2018;1073(3):032059.
  51. Runtu F, Ichwan S, Wanandi SI, Hardainy NS. Evaluating the potential of NANOG as a glioma malignancy biomarker. Journal of Physics: Conference Series. 2018;1073(3):032057.
  52. Dewi S, Karsono R, Praman S, Wanandi SI. Expression profile of stem cell pathway genes in patients with advanced breast cancer after neoadjuvant therapy. Journal of Physics: Conference Series. 2018;1073(3):032037.
  53. Humonobe AI, Syahrani RA, Wanandi SI. Effect of hypoxia on ALDH1A1 expression with MCF-7 human breast cancer cells and its correlation with Oct-4 pluripotency gene expression. Journal of Physics: Conference Series. 2018;1073(3):032062.
  54. Hosea R, Hardiany NS, Ohneda O, Wanandi SI. Glucosamine decreases the stemness of human ALDh+ breast cancer stem cells by inactivating STAT3. Oncology Letters. 2018;16(4):4737-4744.
  55. Purnamawati, Pawitan JA, Rachman A, Wanandi SI. Effects of umbilical cord- and adipose-derived stem cell secretomes on ALDH1A3 expression and autocrine TGF-β1 signaling in human breast cancer stem cells. F1000 Research. 2018;7.
  56. Hardiany NS, Huang P, Dewi S, Paramita R, Wanandi SI. Analysis of pluripotency marker expression in hyman glioblastoma multiforme cells treated with conditioned medium of umbilical cord-derived mesenchymal stem cells. F1000 Research. 2018;7.
  57. Moenadjat Y, Siregar NC, Wanandi SI, Sadikin M. Qualitative study on endothelial cell-to-cell-junction disassembly in severe burn injury. The New Ropanasuri Journal of Surgery. 2018;2(1):1-7.
  58. Prijanti AR, Iswanti FC, Ferdinal F, Wanandi SI, Sadikin M. Hypoxia increased malondialdehyde from membrane damages is highly correlated to HIF-1α but not to renin expression in rat kidney. IOP Conference Series Earth and Environmental. 2019;217(1):012062.
  59. Hardiany NS, Yohana Y, Wanandi SI. The impact of conditioned medium of umbilical cord-derived mesenchymal stem cells toward apoptosis and proliferation of glioblastoma multiforme cells. IOP Conference Series Earth and Environmental. 2019;217(1):012035.
  60. Hardiany NS, Yohana Y, Wanandi SI. TNFR, TRAF2, NF-kB mRNA levels of glioblastoma multiforme cells treated by conditioned medium of umbilical cord-derived mesenchymal stem cells. The Indonesian Biomedical Journal. 2019;11(2).
  61. Amanku BR, Ichwan S, Wanandi SI, Hardiany NS. The difference of hypoxia inducible factor-2α mRNA expression in high-grade and low-grade glioma tissue. Indonesia Journal of Cancer. 2019;13(2):29-34.

PENGHARGAAN

  1. 2004 : Satyalancana Karya Satya 10 Tahun
  2. 2005 : Poster Award Winner-CME FKUI
  3. 2005 : Poster Terbaik-MRU FKUI
  4. 2007 : Poster Riset RUUI-FKUI
  5. 2011 : Poster terbaik “Seminar Nasional hasil Penelitian Hibah Bersaing Tahun 2011” − DRPM UI
  6. 2011 : Consolation prize in in the scientific paper poster presentation-The 7th Malaysia Indonesia Brunei Medical Science Conference
  7. 2013 :  Best Poster − The 2nd International Seminar and Workshop on Stem Cell and Clinical Biology: Stem Cell and Disorder of Sex Development UNDIP Semarang
  8. 2013 : Periset FKUI Potensial berdasarkan H-Index di Scopus
  9. 2013 : Riset FKUI Potensial Kategori II berdasarkan akumulasi Impact Factor Journal
  • 2013 : Periset FKUI productif berdasarkan jumlah artikel di SCOPUS
  • 2017 : Travel Grant ­− The 42nd Annual Meeting of Korean Cancer Association with International Cancer Conference
  • 2016 : DIIB Award Kategori INOVASI−UI
  • 2016 : DIIB Award Kategori Kekayaan Intelektual
  • 2016 : 108 Inovasi Indonesia Prospektif−Business Inovation Center LIPI
  • 2017 : DIIB Award kategori INOVASI
  • 2017 : 109 Inovasi Indonesia Prospektif−Business Inovation Center LIPI
  • 2017 : Juara 1 Ketua Program Studi Berprestasi tingkat Universitas Indonesia
  • 2018 : Juara 1 Dosen Berprestasi tingkat Universitas Indonesia
  • 2018 : Juara 1 Dosen Berprestasi tingkat Nasional (Diktendik Award)
  • 2018 : Satyalancana Karya Satya 30 Tahun

PATEN

  1. 2019 : Metode isolasi sel punca kanker payudara manusia (CD24-/CD44+) secara in vitro sebagai sel lestari (cell line) – Nomor Paten IDP000056854
  2. 2019 : Suatu metode penetapan pembentukan mamosfer seacara in vitro sebagai predictor tumorigenik sel punca kanker payudara – Nomor Paten IDP000060309
  3. 2019 : Uji in silico dan in vitro senyawa Androgafolida untuk menurunkan ketahanan hidup sel punca kanker payudara CD24-/CD44+ secara spesifik melalui interaksinya dengan protein apoptosis Caspase-9 dan Caspase-3 – Nomor Paten IDP000060306

JABATAN DAN ORGANISASI

  1. Staf pengajar muda Departemen Biokimia dan Biologi Molekuler
  2. Editor Majalah Medical Journal Indonesia
  3. Koordinator Penelitian Departemen Biokimia dan Biologi Molekuler
  4. Sekretaris Program Doktor Ilmu Biomedik FKUI
  5. Koordinator Pendidikan S2 Departemen Biokimia dan Biologi Molekuler
  6. Staf Pengajar Departemen Biokimia dan Biologi Molekuler
  7. Sekretaris MRU FKUI
  8. Asisten Manajer Pendidikan S3 FKUI
  9. Lektor Departemen Biokimia dan Biologi Molekuler
  10. Ketua Program Magister Ilmu Biomedik FKUI
  11. Ketua Divisi Resources Department of Medical Research Unit
  12. Anggota Senat Akademik Fakultas
  13. Lektor Kepala Departemen Biokimia dan Biologi Molekuler
  14. Ketua Moleculer Biology and Proteomics Core Facilities-IMERI FKUI
  15. Anggota Komite Etik Penelitian Kedokteran-RS Kanker Dharmais
  16. Ketua Tim Teknis Peralatan dan Fasilitas-IMERI FKUI
  17. Ethical Committee for Medical Research-Stem Cell and Cancer Institute
  18. Anggota Ikatan Dokter Indonesia (IDI)
  19. Anggota Perhimpunan Biokimia dan Biologi Molekuler Indonesia (PBBMI)
  20. Anggota Federation of Asian and Oceanian Biochemist and Molecular Biologist (FAOBMB)
  21. Pendiri Konsorsium Ilmu Biomedik Indonesian (KIBI)
  22. Anggota European Society for Medical Oncology (ESMO)
  23. Sekretaris Konsorsium Ilmu Biomedik Indonesia
  24. Ketua Konsorsium Ilmu Biomedik Indonesia

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